GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7116495 | 1 | rs4945426 | chr11:71748146 | FAM86C | chr11:71498557-71512276:+ | -0.32 | -3.91 | 0.000107 | Severe influenza A (H1N1) infection |
| THCA | cis | rs7116495 | 1 | rs4945434 | chr11:71759087 | FAM86C | chr11:71498557-71512276:+ | -0.32 | -3.91 | 0.000107 | Severe influenza A (H1N1) infection |
| THCA | cis | rs7116495 | 1 | rs4945435 | chr11:71759219 | FAM86C | chr11:71498557-71512276:+ | 0.31 | 3.9 | 0.000111 | Severe influenza A (H1N1) infection |
| THCA | cis | rs9387478 | 1 | rs4945584 | chr6:117750980 | DCBLD1 | chr6:117803820-117891018:+ | 0.51 | 11.14 | 9.16E-26 | Lung cancer |
| THCA | cis | rs9387478 | 1 | rs4945584 | chr6:117750980 | GOPC | chr6:117639351-117923681:- | 0.24 | 7.01 | 7.92E-12 | Lung cancer |
| THCA | cis | rs494562 | 1 | rs494562 | chr6:86117129 | NT5E | chr6:86159302-86205496:+ | 0.23 | 3.66 | 0.000284 | Blood metabolite levels;Metabolic traits |
| THCA | cis | rs4947019 | 1 | rs4947015 | chr6:110052515 | AKD1 | chr6:109814059-110012415:- | -0.45 | -6.79 | 3.28E-11 | Hematological parameters |
| THCA | cis | rs4947019 | 1 | rs4947015 | chr6:110052515 | FIG4 | chr6:110012424-110146634:+ | -0.26 | -3.6 | 0.00035 | Hematological parameters |
| THCA | cis | rs4947019 | 1 | rs4947019 | chr6:110090049 | AKD1 | chr6:109814059-110012415:- | -0.45 | -6.86 | 2.1E-11 | Hematological parameters |
| THCA | cis | rs4947019 | 1 | rs4947019 | chr6:110090049 | FIG4 | chr6:110012424-110146634:+ | -0.29 | -4.16 | 3.8E-5 | Hematological parameters |
| THCA | cis | rs4947534 | 1 | rs4947534 | chr7:56079094 | GBAS | chr7:56032296-56067871:+ | -0.3 | -8.19 | 2.38E-15 | Blood metabolite levels;Amino acid levels |
| THCA | cis | rs4947534 | 1 | rs4947534 | chr7:56079094 | PHKG1 | chr7:56148675-56160689:- | -0.29 | -5.41 | 1.02E-7 | Blood metabolite levels;Amino acid levels |
| THCA | cis | rs4948102 | 1 | rs4948102 | chr7:56097265 | GBAS | chr7:56032296-56067871:+ | -0.31 | -8.38 | 5.85E-16 | Plasma homocysteine levels (post-methionine load test) |
| THCA | cis | rs4948102 | 1 | rs4948102 | chr7:56097265 | PHKG1 | chr7:56148675-56160689:- | -0.29 | -5.36 | 1.28E-7 | Plasma homocysteine levels (post-methionine load test) |
| THCA | cis | rs7551345 | 1 | rs4949371 | chr1:31735880 | ZCCHC17 | chr1:31769842-31837780:+ | -0.3 | -5.61 | 3.47E-8 | Schizophrenia |